Aggravation of polycystic kidney disease in Han:SPRD rats by buthionine sulfoximine.

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Aggravation of polycystic kidney disease in Han:SPRD rats by buthionine sulfoximine.

The administration of ammonium chloride or of sodium or potassium bicarbonate has marked effects on the development of polycystic kidney disease (PKD) in Han:SPRD rats. Because of the possibility that these effects are mediated by changes in redox metabolism, the aim of this study was to determine whether depletion of glutathione, the most abundant and important cellular thiol and scavenger of ...

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23 Buthionine sulfoximine (BSO) is a specific inhibitor of γ-glutamylcysteine synthetase, thus 24 blocking the synthesis of glutathione (GSH). It is known that this makes that BSO affects melanin 25 synthesis because of the role of thiols in melanogenesis. However, BSO may also react with the 26 intermediate oxidation products of melanogenesis, a possibility that has not been investigated from ...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 1997

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.v881283